The Formation of Methemoglobin
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چکیده
منابع مشابه
Antioxidant effect of different vitamins on methemoglobin production: An in vitro study
Nitrite intoxication occurs frequently in ruminants and equines. The most common treatment of this disorder is administration of 1% methylene blue, although the use of some antioxidant agents e.g. vitamins and complementary treatment may also be useful. The aim of this study was to evaluate the in vitro antioxidative effects of some vitamins on methemoglobinemia induced by sodium nitrite. For t...
متن کاملDevelopment of methemoglobin-based biological dosimetry in gamma–irradiated mice
Background: A new biological dosimeter based on methemoglobin level was developed in this study. Materials and Methods: Methemoglobin level in erythrocytes from mice subjected to &gamma rays from a 60Co source was detected using the methemoglobin kit. The dose range was from 0.5 to 8 Gy and the dose rate was 0.5 Gy/min. Results: The results demonstrate that methemoglobin level increases with in...
متن کاملMethemoglobin formation and reduction in man and various animal species.
SMITH, JOSEPH E., AND ERNEST BEUTLER. Methemoglobin formation and reduction in man and various animal species. Am. J. Physiol. 2 I o(2) : 34.7-350. 1 g66.-The rate of methemoglobin formation and reduction in man, goats, sheep, horse, cattle, and pigs was studied. Methemoglobin formation in the various species was studied by the addition of sodium nitrite to hemoglobin solutions, and methemoglob...
متن کاملFructation Induces Hemin Degradation in Methemoglobin
Under prolonged diabetic conditions, HbA1c is produced from normal hemoglobin (HbA0) through a non-enzymatic glycosylation or glycation, a process which enhances the hemoglobin susceptibility to be auto-oxidized to methemoglobin (metHb). Here we are reporting that the non-enzymatic reaction between fructose and metHb (metHb fructation) induces significant changes in the gl...
متن کاملInterspecies variability in propylene glycol dinitrate-induced methemoglobin formation.
Interspecies variability of propylene glycol dinitrate (PGDN)-induced methemoglobin formation was studied in vitro employing erythrocytes from four separate species. The net rate of methemoglobin formation was significantly different among species with dog greater than guinea pig greater than rat greater than or equal to human. This order of susceptibility was maintained in stroma-free hemolysa...
متن کاملStudies of Methemoglobin Concentrations of Three Human Erythrocyte Genotypes (Hb AA, Hb AS, and Hb SS) in the Presence of Five Antimalarial Drugs
Background: Malaria remains the world’s most devastating human parasitic infection. Our goal was to assess the capacity of increasing concentrations of five antimalarial drugs (FansidarTM, HalfanTM, Quinine, CoartemTM and Chloroquine phosphate) to elicit the generation of methemoglobin in three human erythrocyte genotypes (Hb AA, Hb AS and Hb SS). Materials and Methods: Spectrophotometric metho...
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